Fecal Microbiota Transplant (FMT)

At OU Health, you benefit from access to specialists who are highly experienced in managing and treating complex bowel conditions. OU Health offers fecal microbiota transplant (FMT), an FDA-approved therapeutic intervention that helps restore balance in your gut bacteria by introducing healthy microbiota. FMT is especially effective for patients with recurrent Clostridioides difficile (C. diff) infections, which can be debilitating and even life-threatening.

What Is Fecal Microbiota Transplant?

FMT or intestinal microbiota transplant is a good bacteria replacement therapy that introduces healthy microbiota into the gut to restore balance and fight off harmful bacteria like C. diff. It’s a safe, effective option for patients who have not responded to conventional first-line antibiotic therapy for C. diff.

What are the Symptoms of C. Diff?

Symptoms of Clostridioides difficile can include:

• Watery diarrhea
• Fever
• Belly pain and cramping
• Nausea and vomiting
• Loss of appetite and weight loss
• Some people with C. diff have no symptoms, but they can still pass the infection to others

Why Choose OU Health for FMT?

Oklahoma’s First & Only FDA-Approved FMT Comprehensive Care Program

OU Health is the first and only provider in Oklahoma to offer the advanced therapy of fecal microbiota transplant, using different FDA-approved products, with different formulations and methods of transplant (oral, enema).

Outpatient Convenience

Our fecal microbiota transplant (FMT) procedures are performed in an outpatient setting, making treatment more accessible, convenient, and less invasive. The procedure is quick and considered very safe in the right patient population.

Collaborative Care

Our team includes gastroenterologists, pharmacists, benefit navigators, and nursing staff that all working together to ensure a smooth, supportive experience, in timely manner.

Who Is Eligible for FMT?

Fecal microbiota transplant is ideal for:

• Adults 18 and older with recurrent C. diff after completion of an antibacterial course for recurrent CDI (rCDI)
• Prevention: Prophylactic intervention of another episode of C Diff - after completion of an antibacterial course for recurrent CDI (rCDI)

Treatment Options for Recurrent C. Diff

Treatment is tailored to the patients needs and options include:

• VOWST™ (fecal microbiota spores, live—brpk) capsules – A non-invasive oral option: 4 capsules taken over 3 days, containing freeze-dried, live fecal microbiota.
• REBYOTA® (fecal microbiota, live – jslm) – A quick, 10-minute outpatient enema procedure with no prep or sedation required. Antibiotics are stopped 72 hours prior, and most patients feel relief the next day.

Your Fecal Microbiota Transplant Care Team

Our fecal microbiota transplant (FMT) team of experts collaborates with you to create a custom treatment plan tailored to your unique needs. We are committed to providing expert support, personalized treatment, and compassionate attention throughout your experience.