*Research made possible through this grant is supported by the National
Institute of Diabetes and Digestive and Kidney Diseases, a component of
the National Institutes of Health, under the award number R01DK134316.
NIH/NIDDK U01 GRANT (02/2023 – 01/2029)
PI: Jeanie Tryggestad, MD Department of Pediatrics
Funding Organization: National Institutes of Health (NIH)/ National Institute
of Diabetes and Digestive and Kidney Diseases (NIDDK)
Grant Type: U01
Title of Grant:
Identifying Metabolic and Psychosocial Antecedents and Characteristics
of youth-onset Type 2 diabetes (IMPACT DM)
*Research made possible through this grant is supported by the National
Institute of Diabetes and Digestive and Kidney Diseases, a component of
the National Institutes of Health, under the award number U01DK135007.
OCASCR GRANT (07/2023 – 06/2024)
PI: Archana Unnikrishnan, PhD Department of Biochemistry & Molecular Biology
Funding Organization: Oklahoma Center for Adult Stem Cell Research (OCASCR)
Grant Type: Research
Title of Grant:
Characterization of the molecular heterogeneity of the Intestinal Stem Cells
Dates: 07/01/23 – 06/30/24
Amount Awarded: $149,780
OCAST GRANT (04/2023 – 3/31/2026)
PI: Marisol Castillo-Castrejon, PhD Department of Pathology
Funding Organization: Center for Advancement of Science & Technology (OCAST)
Grant Type: HR23
Title of Grant:
Reduced B cell Estrogen Signaling Contributes to Menopause-associated Weight Gain
Dates: 04/01/2023 – 3/31/2026
Anticipated Cumulative Amount Awarded: $135,000
PHF Team Science GRANTS
PI: Mary Beth Humphrey, MD, PhD, FACP Department of Internal Medicine
Funding Organization: Presbyterian Health Foundation (PHF)
Grant Type: Team Science
Title of Grant:
Gut Microbiome and bone remodeling
Dates: 07/03/2023 – 07/02/2024
Amount Awarded: $100,000
PI: Dean Myers, PhD Department of Physiology
Funding Organization: Presbyterian Health Foundation (PHF)
Grant Type: Team Science
Title of Grant:
Development of a Baboon (Papio anubis) Model of Western Diet and Paternal
Obesity – Mechanisms for Fetal/Offspring Epigenetic Programming
of Metabolic Disorders
Dates: 07/03/2023 – 07/02/2024
Amount Awarded: $100,000
PI: Michael Rudolph, PhD Department of Physiology
Funding Organization: Presbyterian Health Foundation (PHF)
Grant Type: Team Science (year 3)
Title of Grant:
Maternal Exercise Induces Milk Thermogenic Brown Adipose Tissue Activators
that Stimulate Infant Metabolism
Dates: 07/03/2023 – 07/02/2024
Amount Awarded: $100,000
HHDC NOVEL PILOT PROJECT GRANTS
PI: Kathryn Burge, PhD Department of Pediatrics
Funding Organization: Harold Hamm Diabetes Center (HHDC)
Grant Type: Novel Pilot Project – Year 1
Title of Grant:
Microbiota-derived tryptophan metabolites and intestinal tuft cell signaling
in vertical transmission of maternal metabolic phenotype
Dates: 07/01/23 – 06/30/24
Amount Awarded: $70,000
PI: John R. Clegg, PhD Stephenson School of Biomedical Engineering
Funding Organization: Harold Hamm Diabetes Center (HHDC)
Grant Type: Novel Pilot Project – Year 1
Title of Grant:
Maternal Macrophage Immunotherapy: A Novel Strategy to Prevent Developmental
Programming of Metabolic Disease in Obese Pregnancy
Dates: 07/01/23 – 06/30/24
Amount Awarded: $70,000
PI: Sirish Palle, MD Department of Pediatrics
Funding Organization: Harold Hamm Diabetes Center (HHDC)
Grant Type: Novel Pilot Project – Year 1
Title of Grant:
Metabolomic profiling for pediatric NAFLD
Dates: 07/01/23 – 06/30/24
Amount Awarded: $60,457
PI: Amanda Sharpe, PhD Department of Pharmaceutical Sciences
Funding Organization: Harold Hamm Diabetes Center (HHDC)
Grant Type: Novel Pilot Project – Year 1
Title of Grant:
The role of melanocortin-4 receptors on astrocytes in the hypothalamus
on inflammaging, adipocity, and weight regulation
Dates: 07/01/23 – 06/30/24
Amount Awarded: $70,000
PI: Kevin Short, PhD, FACSM Department of Pediatrics
Co-I: Jed Friedman, PhD Department of Physiology
Funding Organization: Harold Hamm Diabetes Center (HHDC)
Grant Type: Novel Pilot Project – Year 1
Title of Grant:
Maternal obesity and diet: Impact on liver and metabolic health during
pregnancy and post-partum
Dates: 07/01/23 – 06/30/24
Amount Awarded: $70,000
PI: David Sparling, MD, PhD Department of Pediatrics
Funding Organization: Harold Hamm Diabetes Center (HHDC)
Grant Type: Novel Pilot Project – Year 1
Title of Grant:
Changes in CRISPLD2 Secretion During Progression of Type 2 Diabetes Mellitus
Dates: 07/01/23 – 06/30/24
Amount Awarded: $63,000
PI: Jian Xu, PhD Department of Physiology
Funding Organization: Harold Hamm Diabetes Center (HHDC)
Grant Type: Novel Pilot Project – Year 1
Title of Grant:
Endothelial Cell-derived FGF21 and Pancreatic β-Cell Survival in Diabetes
Dates: 07/01/23 – 06/30/24
Amount Awarded: $70,000
HHDC NOVEL PILOT PROJECT FOR POSTDOCS GRANT (07/2023 – 06/2024)
PI: Nisha Thomas, PhD Stephenson Cancer Center
Funding Organization: Harold Hamm Diabetes Center (HHDC)
Grant Type: Novel Pilot Project for Post-Docs – Year 1
Title of Grant:
Estrogen Receptor Inhibition Links Unhealthy Adipose Tissue to Diabetes
After Breast Cancer
Dates: 07/01/23 – 06/30/24
Amount Awarded: $70,000
HHDC TEAM SCIENCE GRANTS
PI: Joni Beck, PharmD, BC-ADM, CDE Department of Pediatrics
Funding Organization: Harold Hamm Diabetes Center (HHDC)
Grant Type: Team Science – Year 1
Title of Grant:
Wavelengths-Transitioning for Adolescents to Young Adult with Diabetes
Dates: 07/01/23 – 06/30/24
Amount Awarded: $100,000
PI: Marisol Castillo-Castrejon, PhD Department of Pathology
Funding Organization: Harold Hamm Diabetes Center (HHDC)
Grant Type: Team Science – Year 1
Title of Grant:
Contribution of B cells to obesity and menopause-associated diabetes risk
Dates: 07/01/23 – 06/30/24
Amount Awarded: $100,000
PI: Mary Beth Humphrey, MD, PhD, FACP Department of Internal Medicine
Funding Organization: Harold Hamm Diabetes Center (HHDC)
Grant Type: Team Science
Title of Grant:
Exploring the role of Trem2+ kidney resident macrophages in diabetic kidney disease
Dates: 07/01/23 – 06/30/24
Amount Awarded: $100,000
PI: Stephanie Pierce, MD Department of Obstetrics and Gynecology
Funding Organization: Harold Hamm Diabetes Center (HHDC)
Grant Type: Team Science – Year 2 addendum
Title of Grant:
Pilot RCT Intervention Targeting Elevated Triglycerides with a Point-of-Care
Meter and Omega-3 Fatty Acid to Normalize Triglycerides and Fetal Growth
Dates: 07/01/23 – 06/30/24
Amount Awarded: $289,532
PI: Jeanie Tryggestad, MD Department of Pediatrics
Funding Organization: Harold Hamm Diabetes Center (HHDC)
Grant Type: Team Science – Year 1
Title of Grant:
Metabolic And Glycemic Indices in Children with youth-onset type 2 Diabetes
Mellitus (MAGIC DM)
Dates: 07/01/23 – 06/30/24
Amount Awarded: $100,000
PI: Sangpil Yoon, PhD School of Electrical and Computer Engineering
Funding Organization: Harold Hamm Diabetes Center (HHDC)
Grant Type: Team Science – Year 1
Title of Grant:
Multiplexed imaging of immune cells after islet and beta cell transplantation
Dates: 07/01/23 – 06/30/24
Amount Awarded: $99,908
HHDC-SCC TEAM SCIENCE GRANTS
PI: Kamiya Mehla, PhD Department of Oncology Science
Funding Organization: Harold Hamm Diabetes Center (HHDC)/ Stephenson Cancer
Center (SCC)
Grant Type: HHDC-SCC Team Science – Year 1
Title of Grant:
Pancreatic Cancer and Hyperlipidemia
Dates: 07/01/23 – 06/30/24
Amount Awarded: $100,000
PI: Elizabeth Wellberg, PhD Department of Pathology
Funding Organization: Harold Hamm Diabetes Center (HHDC)/ Stephenson Cancer
Center (SCC)
Grant Type: HHDC-SCC Team Science – Year 1
Title of Grant:
Characterization of the influence of obesity on the in-situ-to-invasive
transition of breast cancer
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