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Harold Hamm Diabetes Center Grant Opportunities

Opportunities for Harold Hamm Diabetes Center members include funding awards and access to core facilities. A variety of funding awards are available to members to encourage the further development of their work. Award applications are evaluated on a competitive, peer-reviewed basis by the Harold Hamm Research Grants Committee and External Review Panel. Additional awards, such as matching awards to other funding opportunities, will be announced if they become available.

Spring 2023 Award Opportunities

Funding Opportunity Summary

The Harold Hamm Diabetes Center (HHDC) is pleased to announce pilot funding opportunities for 2023. The HHDC Pilot Program will consider funding six types of proposals including Team Science proposals, Pre-Team Science proposals, Novel Pilot Projects, Novel Pilot Projects for Post-Docs, Bridge Funding, Equipment grants and a Travel Stipend. Based on a matching gift, the HHDC will award up to $1.6M to researchers to launch investigations for Diabetes research. These funds will be augmented with a collaboration with the Stephenson Cancer Center for projects specifically aimed at collaboration between researchers in diabetes and cancer.

Key Information

HHDC FUNDED PROGRAMS:

  • Team Science Grant: $100,000 per year up to 3 years
  • Novel Pilot Project Grant: $70,000 for up to 2 years
  • Novel Pilot Project Grant for Post-Docs: $70,000 per year for up to 2 years
  • Bridge Grant: $100,000 for 1 year
  • Equipment Grant: Up to $250,000
  • Travel Stipend: Up to $2,500

HHDC-SCC FUNDED PROGRAMS:

  • Team Science Grant: $100,000 per year up to 3 years
  • Novel Pilot Project Grant: $70,000 per year for up to 2 years

Funding Priorities:

Applications should be closely aligned with the mission of the HHDC to increase understanding about the causes and consequences of diabetes and closely related cardiometabolic conditions like obesity, liver disease, and cancer, as well as strategies for prevention or treatment of these conditions. Additionally, proposals that address one or more of the following themes are HHDC funding priorities:

  • Theme 1: Diabetes and Obesity Across the Lifespan. Proposals that aim to gain basic science and clinical knowledge on the inter-relationship of obesity and diabetes across the lifespan. For example:
    • Genetic, epigenetic, and environmental basis of susceptibility to developing insulin resistance, metabolic dysregulation, inflammation, macrovascular and microvascular diabetic complications, or obesity across the lifespan.
  • Theme 2: Pancreas and Beta Cell Function. We encourage investigators interested in all aspects of pancreatic function in type 1, type 2, or gestational diabetes and associated conditions to submit their research proposals in this area. This includes studies that utilize pancreatic tissue samples, relevant cell culture and animal models, and human-based studies of in-vivo and ex-vivo pancreatic function. Some examples include:
    • Physiology and mechanisms for insulin and c-peptide production, secretion, or action; modulation of pancreatic function with obesity, diabetes, aging, or related conditions.
    • Strategies to modulate, maintain, or restore insulin secretion in the presence of diabetes, pre-diabetes, or during the aging process.
    • Genetic, autoimmune, or environmental processes leading to reduction in beta cell mass or function.
    • Studies of the action of pancreatic-derived proteins such as glucagon, somatostatin, or digestive enzymes, especially if the intent is to understand the metabolic causes and consequences of obesity or diabetes.

      If your research could benefit from use of human pancreatic samples, please contact us about opportunities to acquire these tissues locally.
  • Theme 3: Diabetes/Obesity and Cancer. Proposals that aim to answer questions about the relationship surrounding obesity, diabetes, and cancer. Some examples include:
    • Mechanisms through which obesity and/or diabetes and co-morbidities promote cancer risk, or progression to lethal disease. Successful applications will leverage basic science tools across disease models to address a transdisciplinary problem.
    • The impact of cancer therapies or cancer growth on metabolic health in basic, preclinical, or clinical studies. Successful applications will evaluate long term effects of physiologically relevant cancer treatments on issues such as diabetes risk, cachexia, neurodegeneration, or other adverse outcomes.
    • Disparities in obesity/diabetes or cancer risk/prognosis that associate with poor health outcomes in one of these areas (e.g., in obesity-associated cancers). Successful applications will explore the social, economic, or individual contributors to those inequalities.

COVID-19 Related Proposals
Proposals studying Covid-19 are welcome if they are related to the HHDC mission, e.g. exploring the relationship between diabetes and Covid-19 presentation or outcomes, and there is a plan for follow-on studies by applying for extramural funding.

Eligibility
The PI of any HHDC grant application must be a Member of HHDC; the co-investigators (Multi-PI) do not have to be members at the time of application but if successful are required to become Members or Associate Members of HHDC during the tenure of the grant. Grant recipients may not apply for or hold another HHDC grant or Team Science grant as project PI or MPI.

Application Process

LETTER OF INTENT
Letter of Intents are due to HHDCGrants@ouhsc.edu by 5 p.m. on January 16, 2023. Applications selected for full application submission will be notified by February 6, 2023. The projected start date for the award will be July 1, 2023.

LOIs are due January 16, 2023, by 5:00 p.m.,and must include a Face Page (Template Provided), which includes the following:

  • Investigator(s)' NIH Biosketches
  • Personal Statement
  • Project Title
  • Project Summary
  • Project Specific Aims

FULL APPLICATION
Application attachments will vary by proposal type. Please see grant specific instructions below for further information.

For all applications, the sponsored programs grant routing form and completed application must be received by ORA at least three business days prior to the March 17, 2023 grant application deadline. You must submit an electronic routing form using SoonerTrack. A copy of the application must be attached to the SoonerTrack ticket or emailed for review to your Sponsored Program Administrator. Once the review is complete, the Face Page of the grant application must be signed by the ORA official before the PI submits the final application to HHDC.

Note: External Applicants will need to use their own institution’s offices for any grant processing, and comply with the March 17, 2023 HHDC grant application deadline above.

SUBMISSION AND REVIEW OF FINAL APPLICATION
Send the final application by e-mail to HHDCGrants@ouhsc.edu no later than 5 p.m. on Friday, March 17, 2023. Please title the application attached to the email: HHDC <Type of Grant> Grant-[PI Last Name, First Name]. Please submit the application as a single file in pdf format. Failure to follow these steps could cause your application to be overlooked and not reviewed by the HHDC Grants Review Committee.

For 2023 and onward, the HHDC Grants Review Committee will review and award grants in consultation with two outside reviewers. Outside reviewers will be specifically selected for each application, for their relevant subject matter expertise. Applicants are encouraged to provide the names of two potential outside reviewers in their LOI. Final selection of the two outside reviewers will be made by the HHDC Grants Review Committee. Once appointed, the internal committee and two outside reviewers will evaluate the proposal to come to a funding decision.

PROGRAM APPLICATION AND GUIDELINES
All applications will follow the HHDC Application Form, Terms and Guidelines found here:

HHDC Diabetes Programs:

HHDC-SCC Diabetes/Cancer Programs:

For questions or for special exception of the announcement approval, please contact Ryan Sease at ryan-sease@ouhsc.edu or Lark Zink at lark-zink@ouhsc.edu.