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OU Health Sciences Center Receives Grant for Opioid Management in Older Adults

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OKLAHOMA CITY -- Chronic pain can be quite common among older adults as they face conditions such as arthritis and neuropathy. Treating pain in older adults requires special considerations, however, especially when it comes to opioids.

The University of Oklahoma Health Sciences Center recently received a $2.5 million federal grant to tailor methods of treating chronic pain to the older adult population – with an emphasis on decreasing the use of opioids – and to disseminate those best practices to primary care clinics across Oklahoma. The grant is from the Agency for Healthcare Research and Quality, the lead federal agency charged with improving the safety and quality of America’s healthcare system.

In recent years, the OU Health Sciences Center has made significant contributions to the medical profession’s understanding of the risks and benefits of using opioids to treat chronic pain. However, much of that work has focused on the general population, rather than older adults specifically. This grant will allow physicians and researchers to concentrate solely on older adults, and to establish standards of pain management that prioritize non-opioid medications and treatments.

“The older population has a much different relationship with opioids than the younger population does,” said one of the grant’s three principal investigators, Zsolt Nagykaldi, Ph.D., Director of Research for the Department of Family and Preventive Medicine in the OU College of Medicine. “In the younger population, the No. 1 problem is typically misuse, while in the older population, the bigger problems are interactions between opioids and other medications and other health conditions, as well as a higher risk of falls.”

There are numerous reasons for limiting or avoiding opioid prescriptions in older adults, said co-principal investigator Steven Crawford, M.D., Senior Associate Dean for the OU College of Medicine. Metabolism slows as people age, which can increase the effects of opioids. Conditions like emphysema and sleep apnea complicate the use of opioids, Crawford said, and other medications may interact poorly with opioids. Opioids also cause constipation, which can affect the body’s systems and eventually lead to serious issues.

However, there are many alternatives to opioids. Non-opioid medications may be an option, although care must be exercised with anti-inflammatory drugs like ibuprofen, which can damage the kidneys and increase the risk of internal bleeding, among other complications, Crawford said. There are many non-pharmacologic possibilities, such as physical therapy, topical agents, acupuncture, massage, meditation and exercise. Those are also important options if patients are decreasing their opioid use slowly over time.

“Regular physical activity is very important for managing chronic pain because pain gets worse if people sit for a long time,” said geriatrician and co-principal investigator Lee Jennings, M.D., Chief of the Section of Geriatrics in the Department of Medicine, OU College of Medicine. Jennings is also director of the Oklahoma Healthy Aging Initiative (OHAI), which provides gentle exercise opportunities and falls prevention classes (including via Zoom) across Oklahoma. OHAI’s free programming will be emphasized as part of the overall program.

“It’s not easy to treat older adults with chronic pain, so this grant will allow us to help patients and their physicians to understand and have access to alternatives to opioids,” Jennings said. “It’s very important to have safe opioid prescribing practices and to make sure that patients understand the risks, but we have to think through other ways to manage pain. It’s not always possible to make someone totally pain-free, but we also don’t want to put someone at risk for a fall because they’re taking a medication that has a sedating effect. We want them to continue doing the activities that enrich their lives. We don’t want people to stop doing the things they enjoy because that can lead to social isolation and loneliness, which ultimately leads to poorer health.”

Because primary care clinics provide most of the care for older adults with chronic pain, the OU Health Sciences Center will be working with up to 50 clinics across Oklahoma. Community panels, comprised of both patients and clinicians, will provide insight into the needs specific to each area. The OU Health Sciences Center has an extensive network of relationships with rural clinics across the state to share best practices and provide hands-on assistance; this grant will enable further outreach on a topic that’s important to many Oklahomans.

“New medical guidelines, if they follow the natural course of things, can take years to become wedded into the practices of clinics,” Crawford said. “This type of program allows us to accelerate that process by working with clinics to improve the quality of life for their patients.”



One of nation’s few academic health centers with seven professional colleges — Allied Health, Dentistry, Medicine, Nursing, Pharmacy, Public Health and Graduate Studies — the University of Oklahoma Health Sciences Center serves approximately 4,000 students in more than 70 undergraduate and graduate degree programs on campuses in Oklahoma City and Tulsa. For more information, visit


OU Health — along with its academic partner, the University of Oklahoma Health Sciences Center — is the state’s only comprehensive academic health system of hospitals, clinics and centers of excellence. With 11,000 employees and more than 1,300 physicians and advanced practice providers, OU Health is home to Oklahoma’s largest physician network with a complete range of specialty care. OU Health serves Oklahoma and the region with the state’s only freestanding children’s hospital, the only National Cancer Institute-Designated OU Health Stephenson Cancer Center and Oklahoma’s flagship hospital, which serves as the state’s only Level 1 trauma center. Becker’s Hospital Review named University of Oklahoma Medical Center one of the 100 Great Hospitals in America for 2020. OU Health’s oncology program at Stephenson Cancer Center and University of Oklahoma Medical Center was named Oklahoma’s top facility for cancer care by U.S. News & World Report in its 2020-21 rankings. OU Health was also ranked by U.S. News & World Report as high performing in these specialties: Colon Surgery, COPD and Congestive Heart Failure. OU Health’s mission is to lead healthcare in patient care, education and research. To learn more, visit