Stefano Tarantini, PhD
- Research Program: Geroscience
- Position: College of Medicine, Assistant Professor of Research, Department of Biochemistry and Molecular Biology
Biography
Since his early career, Dr. Tarantini's research efforts have been focused on investigating age-related cerebrovascular changes and their impact on cognition. Dr. Tarantini merges his experience as a biomedical engineering graduate, with his expertise in the study of vascular aging and age-related diseases, by developing experimental approaches to understand the molecular mechanisms underlying the development of age-related vascular cognitive impairment.
Dr. Tarantini's research efforts have been recognized nationally and internationally as he the recipient of meritorious research awards from the American Aging Association, American Physiological Society, the Microcirculatory Society, and 2 fellowships from the American Heart Association. His current research objectives are to apply a wide spectrum of molecular, cellular, and intra-vital physiological approaches to investigate the effects of unhealthy diets, cancer treatments, and anti-aging nutritional interventions on the shared basic mechanisms of cellular senescence, vascular aging, and cognitive decline associated with accelerated aging.
Publications
- Graduate School
- Reynolds Oklahoma Center on Aging
- University of Oklahoma Health Sciences Center
- Undergraduate School
- University of Central Oklahoma
- Dietary interventions in Age-related Disease
- Intermittent Fasting
- GeroOncology
- Combination Therapies
- Neurovascular Unit Senescence
- Nicotinamide mononucleotide (NMN) supplementation rescues cerebromicrovascular endothelial function and neurovascular coupling responses and improves cognitive function in aged mice
- Treatment with the mitochondrial-targeted antioxidant peptide SS-31 rescues neurovascular coupling responses and cerebrovascular endothelial function and improves cognition in …
- Pharmacologically-induced neurovascular uncoupling is associated with cognitive impairment in mice
- Nrf2 deficiency exacerbates obesity-induced oxidative stress, neurovascular dysfunction, blood–brain barrier disruption, neuroinflammation, amyloidogenic gene expression, and Cognitive Decline in Mice, Mimicking the Aging Phenotype
- Circulating IGF-1 deficiency exacerbates hypertension-induced microvascular rarefaction in the mouse hippocampus and retrosplenial cortex: implications for cerebromicrovascular
- Demonstration of impaired neurovascular coupling responses in TG2576 mouse model of Alzheimer’s disease using functional laser speckle contrast imaging
- Obesity in aging exacerbates neuroinflammation, dysregulating synaptic function-related genes and altering eicosanoid synthesis in the mouse hippocampus: potential role in …
- Insulin-like growth factor 1 deficiency exacerbates hypertension-induced cerebral microhemorrhages in mice, mimicking the aging phenotype
- Treatment with the poly (ADP-ribose) polymerase inhibitor PJ-34 improves cerebromicrovascular endothelial function, neurovascular coupling responses and cognitive performance …