Judith James, MD, PhD

  • Research Program: Geroscience
  • Position: Rheumatology/Immunology/Allergy, Professor of Pathology, Professor of Medicine, George Lunn Cross Professor of Research

Biography

Judith A. James, MD, PhD, is Chair of the Arthritis and Clinical Immunology Program and holds the Lou Kerr Chair in Biomedical Research at the Oklahoma Medical Research Foundation. Dr. James is also the Associate Vice Provost for Clinical and Translational Science and Professor of Medicine and Pathology at the University of Oklahoma Health Sciences Center.

Dr. James’ research interests focus on understanding the etiology and pathogenesis of lupus, Sjogren’s syndrome and related disorders, the evolution and pathogenic mechanisms of autoantibodies in systemic rheumatic disease, and the interplay of genetic risk and environmental responses in systemic autoimmunity. Her work has made seminal contributions to understanding how autoimmune diseases start and the concept of humoral epitope spreading. She has published over 280 articles in journals such as the New England Journal of Medicine, Nature Medicine, Journal of Experimental Medicine, Annals of Rheumatic Disease and Arthritis and Rheumatology for example. Dr. James currently serves as the principal investigator for several large, multi-investigator NIHfunded grants, such as the U54 Oklahoma Shared Clinical & Translational Resources from NIGMS, UM1 Autoimmunity Center of Excellence from NIAID, and P30 Rheumatic Disease Research Cores Center from NIAMS.

Dr. James has conducted lectures for the American College of Rheumatology, International Systemic Lupus Erythematosus Meetings, among others. Dr. James has received several prestigious awards including the Evelyn V. Hess Award from the Lupus Research Foundation, the Stanley J. Korsmeyer award from the American Society for Clinical Investigation, the Presidential Early Career Award for Scientists and Engineers and the Dubois’ Award from the American College of Rheumatology. She is a member of NIAMS Council with the National Institutes of Health and recently served as the elected Secretary-Treasurer of the American Society of Clinical Investigation. She has served on several other NIH advisory committees and chaired an NIH Roundtable regarding preclinical autoimmunity.

Dr. James also was selected to provide testimony supporting the NIH at the Noel Laureates’ Hearing for the US Senate Appropriations Subcommittee. Dr. James received her medical degree and PhD in Immunology from the Oklahoma Health Sciences Center and is a board certified adult Rheumatologist. She continues to practice adult rheumatology, focusing on SLE, incomplete lupus, Sjogren’s syndrome, and related rheumatic diseases.

Email

Judith-James@omrf.org

Publications

Health Education
  • Graduate School
  • Arthritis & Immunology Oklahoma Medical Research Foundation
    Oklahoma City, OK
  • Internal Medicine-Rheumatology University of Oklahoma Health Science Center
    Oklahoma City, OK
  • Undergraduate School
  • Chemistry Oklahoma Baptist University
    Shawnee, OK
Research Interests:
  • Rheumatology
  • Arthritis
  • Lupus
  • Sjogren's Syndrome
  • Multiple Sclerosis
Publications
  • Multiple Sclerosis is rare in Epstein-Barr Virus-seronegative children with central nervous system inflammatory demyelination 2021
  • Epstein Barr virus and autoimmune responses in systemic lupus erythematosus 2021
  • Epstein-Barr functional mimicry: Pathogenicity of oncogenic latent membrane Protein-1 in systemic lupus erythematosus and autoimmunity 2021
  • T Cell Mediated Conversion of a Non-Anti-La Reactive B Cell to an Autoreactive Anti-La B Cell by Somatic Hypermutation 2021
  • Modular gene analysis reveals distinct molecular signatures for cutaneous lupus patient subsets 2021
  • Genetic association of a gain of function interferon gamma receptor 1 (IFNGR1) polymorphism and the intergenic region LNCAROD/DKK1 with Behçet's disease 2021
  • Deep sequencing reveals a DAP1 regulatory haplotype that potentiates autoimmunity in systemic lupus erythematosus 2020
  • TLR engagement induces ARID3a in human blood hematopoietic progenitors and modulates IFNa production 2020
  • ARID3a expression in human hematopoietic stem cells is associated with distinct gene patterns in aged individuals 2020
  • Emerging evidence of a COVID-19 thrombotic syndrome has treatment implications 2020