Deepa Sathyaseelan, PhD
- Research Program: Geroscience
- Position: Asst. Professor, Department of Biochemistry & Molecular Biology
Biography
My primary research interest is understanding the role of inflammation in aging and age-associated diseases. Chronic, low-grade inflammation (inflammaging) is a hallmark of aging and age-associated diseases. My current research aim to identify the molecular pathways responsible for inflammaging and to determine if inflammation is a causative factor in aging and age-associated diseases. Necroptosis (programmed necrosis) is a cell death pathway that plays a major role in chronic inflammation; however, little is known about the role of necroptosis in the age-associated chronic inflammation or aging. My studies have shown that necroptosis increase with age and blocking necroptosis reduced inflammation in a mouse model of accelerated aging. Using genetic and pharmacological approaches to block/reduce necroptosis in mice, I am studying the role of necroptosis-induced chronic inflammation on lifespan and healthspan of mice. I am also studying the role of necroptosis in the development of chronic liver diseases (CLD) such as fibrosis and hepatocellular carcinoma, which increases with age. Our ongoing studies will use novel mouse models to gain a better understanding of the role of necroptosis in CLD development that will help to discover new targets for therapeutic intervention. I have published 34 articles (7 corresponding author and 15 first author) and is the recipient of grants from the American Heart Association, the American Federation for Aging Research and the National Institute on Aging. I have received Junior faculty Travel award from the American Aging association and is a Trainee at the Summer Training in Aging and NCI-funded Transdisciplinary Research on Energetics and Cancer. I am a member of the American Federation for Aging Research National Scientific Advisory Council, American Aging Association, Society of Redox Biology and Medicine and American Association for the Study of Liver Diseases.
Publications
- Graduate School
- University of Cambridge, UK
- Kobe Pharmaceutical University, Japan
- University of Kerala, India
- Inflammation
- Necroptosis
- Liver Cancer
- Aging
- Obesity
Additional Profiles:
- Role of necroptosis in chronic hepatic inflammation and fibrosis in a mouse model of increased oxidative stress 2021
- The potential role of necroptosis in inflammaging and aging 2019
- Accelerated decline in cognition in a mouse model of increased oxidative stress 2019
- Necroptosis increases with age and is reduced by dietary restriction 2018
- Loss of mitochondrial protease ClpP protects mice from diet-induced obesity and insulin resistance 2018
- Lifelong reduction in complex IV induces tissue-specific metabolic effects but does not reduce lifespan or healthspan in mice 2018
- A fish oil diet induces mitochondrial uncoupling and mitochondrial unfolded protein response in epididymal white adipose tissue of mice 2017
- A new mouse model of frailty: the Cu/Zn superoxide dismutase knockout mouse 2017