David Sparling, MD, PhD
- Position: Assistant Professor, Pediatric Diabetes & Endocrinology, Diabetes Research Member
Biography
Dr. Sparling has been interested in the role of adipocytes in inflammation. His initial research focused on the function of gamma secretase in regulating adipocyte/macrophage cross talk, but my current focus has shifted to characterization of a novel adipokine, CRISPLD2, that seems to be regulated in states of adipose cell turnover, with possible regulation of inflammation, and insulin sensitivity.
Furthermore, he's developed a special clinical interest in type 1 diabetes mellitus, and his research focuses both on diagnosis and management of children with type 1 diabetes as the site primary investigator for TrialNet and previously with the Type 1 Diabetes Exchange.
Additional Websites
- Graduate School
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Fellowship, Pediatric Endocrinology
New York-Presbyterian Morgan Stanley Children's Hospital
New York City, NY -
Residency, Pediatrics
Columbia University College of Physicians and Surgeons, New York Presbyterian
New York City, NY -
PhD, Biochemistry
University of Oklahoma Health Sciences Center
Oklahoma City, OK -
Doctor of Medicine
University of Oklahoma College of Medicine
Oklahoma City, OK
- Adipocyte-mediated inflammation
- Type 1 diabetes
- Adipose inflammation
- Insulin signaling
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Inhibition of y-secretase in adipocytes leads to altered IL-6 secretion and adipose inflammation
2020
9(1):325-334. doi: 10.1080/21623945.2020.1788235. PubMed PMID: 32603641; PubMed Central PMCID: PMC7469479.
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Weight Loss Results in Increased Expression of Anti-Inflammatory Protein CRISPLD2 in Mouse Adipose Tissue
2019
2025-2036. doi: 10.1002/oby.22652. PubMed PMID: 31746554; PubMed Central PMCID: PMC6873817.
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Continuous Glucose Monitoring Profiles in Healthy Nondiabetic Participants: A Multicenter Prospective Study
2019
104(10):4356-4364. doi: 10.1210/jc.2018-02763. PubMed PMID: 31127824; PubMed Central PMCID: PMC7296129.
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Macrophage-Derived microRNA-155 Increases in Obesity and Influences Adipocyte Metabolism by Targeting Peroxisome Proliferator-Activated Receptor Gamma
2019
27(11):1856-1864. doi: 10.1002/oby.22616. Epub 2019 Sep 18. PubMed PMID: 31531958; PubMed Central PMCID: PMC6832842.
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Adipocyte-specific blockade of gamma-secretase, but not inhibition of Notch activity, reduces adipose insulin sensitivity
2016
5(2):113-121. doi: 10.1016/j.molmet.2015.11.006. eCollection 2016 Feb. PubMed PMID: 26909319; PubMed Central PMCID: PMC4735659.