Adi Joshi, PhD

Biography

Dr. Joshi’s research is focused on understanding Aryl hydrocarbon Receptor (AhR) signaling in normal liver physiology, as well as in plethora of hepatic and metabolic diseases. His team investigates molecular mechanisms by which endogenous AhR agonist induced expression of AhR target gene, stanniocalcin 2 is responsible for hepatoprotection against chemical, environmental and pharmacological stressors. In his team’s latest endeavor, they are deciphering the role of stanniocalcin 2 in hyperglycemia and obesity. His research employs cutting-edge cellular, molecular and biochemical methodologies, as well as utilizes innovative technologies such as next-generation sequencing and CRISPR mediated genome editing. His long-term objectives are to acquire comprehensive mechanistic understanding of AhR and its target genes in liver and to develop a translational approach to AhR biology through identifying and characterizing therapeutically useful AhR agonists that can protect against liver and metabolic diseases.

Email

Aditya-Joshi@ouhsc.edu

Additional Websites

• Publications
• OUHSC Profile

Research Interests:

• Liver Diseases
• Obesity
• Aryl Hydrocarbon Receptor
• Drug Discovery and Development in vivo models

Notable Work

PEER-REVIEWED RESEARCH PUBLICATIONS

https://www.ncbi.nlm.nih.gov/myncbi/1JmbFfbnF6Rgfc/bibliography/public/

Rindler, P. M., Crewe, C. L., Fernandes, J., Kinter, M., & Szweda, L. I. (2013). Redox regulation of insulin sensitivity due to enhanced fatty acid utilization in the mitochondria. Am J Physiol Heart Circ Physiol, 305(5), H634-643. doi:10.1152/ajpheart.00799.2012

Fernandes, J., Weddle, A., Kinter, C. S., Humphries, K. M., Mather, T., Szweda, L. I., & Kinter, M. (2015). Lysine Acetylation Activates Mitochondrial Aconitase in the Heart. Biochemistry, 54(25), 4008-4018. doi:10.1021/acs.biochem.5b00375

Fernandes, J., Pal, A. K., Kumar, P., Chandrachoodan, P. P., & Akhtar, M. S. (2015). Combined effect of heat shock and chlorine fails to elicit acquired thermal tolerance in labeo rohita spawns. Proc. Natl. Acad. Sci., India, Sect. B Biol. Sci., 86(3), 537-542. doi:10.1007/s40011-014-0478-5

Chandler, J. D., Hu, X., Ko, E. J., Park, S., Lee, Y. T., Orr, M., Fernandes, J., Uppal, K., Kang, S. M., Jones, D. P., & Go, Y. M. (2016). Metabolic pathways of lung inflammation revealed by highresolution metabolomics (HRM) of H1N1 influenza virus infection in mice. Am J Physiol Regul Integr Comp Physiol 311(5), R906-R916. doi:10.1152/ajpregu.00298.2016.

Fernandes, J., Hao, L., Bijli, K. M., Chandler, J. D., Orr, M., Hu, X., Jones, D. P., & Go, Y. M. (2017). From the cover: Manganese stimulates mitochondrial H2O2 production in SH-SY5Y human neuroblastoma cells over physiologic as well as toxicologic range. Toxicol Sci 155(1), 213-223. doi:10.1093/toxsci/kfw196.

Hu, X., Fernandes, J., Jones, D. P., and Go, Y. M. (2017). Cadmium stimulates myofibroblast differentiation and mouse lung fibrosis. Toxicology 383, 50-56. doi:10.1016/j.tox.2017.03.018. Jolyn Fernandes, MS, Ph.D.

Smith, M. R., Fernandes, J*., Go, Y. M., and Jones, D. P. (2017). Redox dynamics of manganese as a mitochondrial life-death switch. Biochem Biophys Res Commun 482(3), 388-398. doi:10.1016/j.bbrc.2016.10.126.*co-first author

Go, Y-M., Fernandes, J., Hu, X., Uppal, K., and Jones D.P. (2017). Mitochondrial network responses in oxidative physiology and disease. Free Radical Biology and Medicine, 116, 31-40. doi:10.1016/j.freeradbiomed.2018.01.005.

Hu, X., Chandler, J. D., Fernandes, J., Orr, M. L., Hao, L., Uppal, K., Neujahr, D. C., Jones, D. P., and Go, Y. M. (2018). Selenium supplementation prevents metabolic and transcriptomic responses to cadmium in mouse lung. Biochim Biophys Acta Gen Subj. S0304-4165(18)30102-8. doi:10.1016/j.bbagen.2018.04.009

Fernandes, J., Chandler, J. D., Liu, K. H., Uppal, K., Go, Y. M., and Jones, D. P. (2018). Putrescine as indicator of manganese neurotoxicity: Dose-response study in human SH-SY5Y cells. Food Chem Toxicol 116(Pt B), 272-280. doi:10.1016/j.fct.2018.04.042.

Fernandes, J., Hu, X., Ryan Smith, M., Go, Y. M., and Jones, D. P. (2018). Selenium at the redox interface of the genome, metabolome and exposome. Free Radic Biol Med 127, 215-227. doi:10.1016/j.freeradbiomed.2018.06.002.

Hu, X., Chandler, J. D., Park, S., Liu, K., Fernandes, J., Orr, M., Smith, M. R., Ma, C., Kang, S. M., Uppal, K., Jones, D. P., and Go, Y. M. (2019). Low-dose cadmium disrupts mitochondrial citric acid cycle and lipid metabolism in mouse lung. Free Radic Biol Med 131, 209-217, doi:10.1016/j.freeradbiomed.2018.12.005.

Fernandes, J., Chandler, J. D., Liu, K. H., Uppal, K., Hao, L., Hu, X., Go, Y. M., and Jones, D. P. (2019). Metabolomic Responses to Manganese Dose in SH-SY5Y Human Neuroblastoma Cells. Toxicol Sci 169(1), 84-94. doi:10.1093/toxsci/kfz028.

Chandler, J. D., Hu, X., Ko, E. J., Park, S., Fernandes, J., Lee, Y. T., Orr, M. L., Hao, L., Smith, M. R., Neujahr, D. C., Uppal, K., Kang, S. M., Jones, D. P., and Go, Y. M. (2019). Low-dose cadmium potentiates lung inflammatory response to 2009 pandemic H1N1 influenza virus in mice. Environ Int 127, 720-729, doi:10.1016/j.envint.2019.03.054.

Fernandes, J., Chandler, J. D., Lili, L. N., Uppal, K., Hu, X., Hao, L., Go, Y. M., and Jones, D. P. (2019). Transcriptome Analysis Reveals Distinct Responses to Physiologic versus Toxic Manganese Exposure in Human Neuroblastoma Cells. Front Genet 10, 676. doi:10.3389/fgene.2019.00676.

Hu, X., Kim, K. H., Lee, Y., *Fernandes, J., Smith, M. R., Jung, Y. J., Orr, M., Kang, S. M., Jones, D. P., and Go, Y. M. (2019). Environmental Cadmium Enhances Lung Injury by Respiratory Syncytial Virus Infection. Am J Pathol 189(8), 1513-1525. doi:10.1016/j.ajpath.2019.04.013.*co-first author Jolyn Fernandes, MS, Ph.D.

Ferranti, E. P., Frediani, J.K., Mitchell, R., Fernandes, J., Li, S., Jones, D.P., Corwin, E., and Dunlop, A.L. (2020). Early Pregnancy Serum Metabolite Profiles associated with Hypertensive Disorders of Pregnancy in African American Women: A Pilot Study. J Pregnancy 2020: 1515321. doi:10.1155/2020/1515321

Corwin E.J., Dunlop, A.L., Fernandes, J., Li, S., Pearce, B. and Jones, D.P. (2020). Metabolites and Metabolic Pathways Associated with Glucocorticoid Resistance in Pregnant African-American Women. Comprehensive Psychoneuroendocrinology. 1-2, 100001.doi:https://doi.org/10.1016/j.cpnec.2020.100001

Shanmugam, G., Wang, D., Gounder, S. S., Fernandes, J., Litovsky, S. H., Whitehead, K., Radhakrishnan, R. K., Franklin, S., Hoidal, J. R., Kensler, T. W., Dell'Italia, L., Darley-Usmar, V., Abel, E. D., Jones, D. P., Ping, P., Rajasekaran, N. S. (2020). Reductive Stress Causes Pathological Cardiac Remodeling and Diastolic Dysfunction. Antioxid Redox Signal 32(18): 1293-1312.doi:10.1089/ars.2019.7808

Bellissimo, M. P., Ziegler, T. R., Jones, D. P., Liu, K. H., Fernandes, J., Roberts, J. L., Weitzmann, M. N., Pacifici, R. and Alvarez, J. A. (2020). Plasma high-resolution metabolomics identifies linoleic acid and linked metabolic pathways associated with bone mineral density. Clinical Nutrition. doi:https://doi.org/10.1016/j.clnu.2020.05.041 (In Press)

Go, Y. M., Zhang, J., Fernandes, J., Litwin, C., Chen, R., Wensel, T. G., Jones, D. P., Cai, J., and Chen, Y. (2020). MTOR-initiated metabolic switch and degeneration in the retinal pigment epithelium. FASEB J. doi:10.1096/fj.202000612R

Fernandes, J., Uppal, K., Liu, K.H., Orr, M., Tran, V., Go, Y-M and Jones, Dean P. Antagonistic Pleiotropy in Mitochondria ROS Signaling Responses to Manganese. CELL-REPORTS-D-20-01741. Pre-print available at SSRN: https://ssrn.com/abstract=3595713 or http://dx.doi.org/10.2139/ssrn.3595713