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Michael Elliott, PhD

  • Membership Level: Diabetes Research Member
  • Gender: Male
Research Interests:
  • Regulation of the blood-retinal barrier
  • Novel modulators of ocular inflammatory responses in diabetic retinopathy

Grant Funding

R01EY028608 (ELLIOTT, MICHAEL H)Sep 1, 2018 - Jun 30, 2022

NIH/NEI
Caveolae-based mechanosensors for conventional outflow regulation
Role: Principal Investigator


R01EY019494 (ELLIOTT, MICHAEL H)Apr 1, 2009 - Jun 30, 2020

NIH/NEI
Role of caveolin-1 in the maintenance of blood-retinal barrier integrity
Role: Principal Investigator


F32EY013674 (ELLIOTT, MICHAEL H)Sep 13, 2001

NIH/NEI
Caveolin in Mammalian Photoreceptor Outer Segements
Role: Principal Investigator

Publications
  • Mol Neurobiol. 2019 Apr 17. PMID: 30997640

    Sphingosine Kinase-1 Is Essential for Maintaining External/Outer Limiting Membrane and Associated Adherens Junctions in the Aging Retina.

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  • Neurobiol Aging. 2018 11; 71:1-12. PMID: 30059797

    Age-related focal loss of contractile vascular smooth muscle cells in retinal arterioles is accelerated by caveolin-1 deficiency

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  • J Gerontol A Biol Sci Med Sci. 2018 Jun 14; 73(7):853-863. PMID: 29905772

    Nrf2 Deficiency Exacerbates Obesity-Induced Oxidative Stress, Neurovascular Dysfunction, Blood-Brain Barrier Disruption, Neuroinflammation, Amyloidogenic Gene Expression, and Cognitive Decline in Mice, Mimicking the Aging Phenotype.

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  • Exp Eye Res. 2018 06; 171:164-173. PMID: 29526795

    Consensus recommendations for trabecular meshwork cell isolation, characterization and culture

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  • Invest Ophthalmol Vis Sci. 2018 03 01; 59(3):1512-1522. PMID: 29625473

    Corneal Epithelial Cells Exhibit Myeloid Characteristics and Present Antigen via MHC Class II

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  • Adv Exp Med Biol. 2018; 1074:593-601. PMID: 29721992

    Photoreceptor Outer Segment Isolation from a Single Canine Retina for RPE Phagocytosis Assay

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  • J Neurochem. 2017 12; 143(5):595-608. PMID: 28902411

    Functional changes in the neural retina occur in the absence of mitochondrial dysfunction in a rodent model of diabetic retinopathy

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  • Mol Vis. 2017; 23:707-717. PMID: 29062222

    . Retinal gene expression responses to aging are sexually divergent

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  • Am J Physiol Lung Cell Mol Physiol. 2017 05 01; 312(5):L760-L771. PMID: 28188225

    Inflammation-induced caveolin-1 and BMPRII depletion promotes endothelial dysfunction and TGF-ß-driven pulmonary vascular remodeling

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  • Methods Mol Biol. 2017; 1609:185-194. PMID: 2866058

    Analysis of Fatty Acid and Cholesterol Content from Detergent-Resistant and Detergent-Free Membrane Microdomains

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  • Sci Rep. 2016 11 14; 6:37127. PMID: 27841369

    Caveolin-1 modulates intraocular pressure: implications for caveolae mechanoprotection in glaucoma

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  • 2017 01; 56:84-106. PMID: 27664379.

    Caveolins and caveolae in ocular physiology and pathophysiology. Prog Retin Eye Res

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  • Diabetologia. 2016 09; 59(9):2026-35. PMID: 27306616

    Extravascular modified lipoproteins: a role in the propagation of diabetic retinopathy in a mouse model of type 1 diabetes

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  • PLoS One. 2016; 11(5):e0154560. PMID: 27195776

    Bloodstream-To-Eye Infections Are Facilitated by Outer Blood-Retinal Barrier Dysfunction

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  • J Biol Chem. 2016 Mar 18; 291(12):6494-506. PMID: 26814131

    Regulation of Phagolysosomal Digestion by Caveolin-1 of the Retinal Pigment Epithelium Is Essential for Vision

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  • Adv Exp Med Biol. 2016; 854:411-8. PMID: 26427439

    Retinal Caveolin-1 Modulates Neuroprotective Signaling

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  • Invest Ophthalmol Vis Sci. 2014 Aug 26; 55(10):6224-34. PMID: 25159208

    Caveolin-1 increases proinflammatory chemoattractants and blood-retinal barrier breakdown but decreases leukocyte recruitment in inflammation

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  • Adv Exp Med Biol. 2014; 801:15-21. PMID: 24664676

    Spatial and temporal localization of caveolin-1 protein in the developing retina

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  • Am J Pathol. 2014 Feb; 184(2):541-55. PMID: 24326256

    Loss of caveolin-1 causes blood-retinal barrier breakdown, venous enlargement, and mural cell alteration

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  • J Lipid Res. 2013 Jun; 54(6):1616-29. PMID: 23468130

    Inhibition of de novo ceramide biosynthesis by FTY720 protects rat retina from light-induced degeneration

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  • Invest Ophthalmol Vis Sci. 2012 Jul 09; 53(8):4595-604. PMID: 22678501

    Oxidative and endoplasmic reticulum stresses mediate apoptosis induced by modified LDL in human retinal Müller cells

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  • J Biol Chem. 2012 Jul 13; 287(29):24092-102. PMID: 22645143.

    Leukemia inhibitory factor coordinates the down-regulation of the visual cycle in the retina and retinal-pigmented epithelium

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  • J Biol Chem. 2012 May 11; 287(20):16424-34. PMID: 22451674

    . Loss of caveolin-1 impairs retinal function due to disturbance of subretinal microenvironment

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  • . J Biol Chem. 2011 Sep 16; 286(37):32491-501. PMID: 21785167

    Alpha-phenyl-N-tert-butylnitrone (PBN) prevents light-induced degeneration of the retina by inhibiting RPE65 protein isomerohydrolase activity

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  • Mol Vis. 2010 Aug 18; 16:1669-79. PMID: 20806040

    High levels of retinal docosahexaenoic acid do not protect photoreceptor degeneration in VPP transgenic mice

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  • Invest Ophthalmol Vis Sci. 2010 Sep; 51(9):4422-31. PMID: 20393115

    Retinal sphingolipids and their very-long-chain fatty acid-containing species

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  • Adv Exp Med Biol. 2010; 664:233-42. PMID: 20238022

    Role of Elovl4 protein in the biosynthesis of docosahexaenoic acid

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  • Adv Exp Med Biol. 2010; 664:567-73. PMID: 20238060

    Correlation between tissue docosahexaenoic acid levels and susceptibility to light-induced retinal degeneration

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  • Mol Vis. 2009 Jun 13; 15:1185-93. PMID: 19536303

    DHA does not protect ELOVL4 transgenic mice from retinal degeneration

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  • Free Radic Biol Med. 2009 Mar 01; 46(5):672-9. PMID: 19121385

    Curcumin protects retinal cells from light-and oxidant stress-induced cell death

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  • J Lipid Res. 2009 May; 50(5):807-19. PMID: 19023138

    High levels of retinal membrane docosahexaenoic acid increase susceptibility to stress-induced degeneration

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  • . Proc Natl Acad Sci U S A. 2008 Sep 02; 105(35):12843-8. PMID: 18728184

    Role of Stargardt-3 macular dystrophy protein (ELOVL4) in the biosynthesis of very long chain fatty acids

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  • Biochemistry. 2008 Mar 25; 47(12):3677-87. PMID: 18303857

    Functional activity of photoreceptor cyclic nucleotide-gated channels is dependent on the integrity of cholesterol- and sphingolipid-enriched membrane domains

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  • Adv Exp Med Biol. 2008; 613:335-41. PMID: 18188962

    Phosphorylation of caveolin-1 in bovine rod outer segments in vitro by an endogenous tyrosine kinase

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  • . J Neurochem. 2008 Jan; 104(2):336-52. PMID: 17944869

    Differential distribution of proteins and lipids in detergent-resistant and detergent-soluble domains in rod outer segment plasma membranes and disks

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  • Invest Ophthalmol Vis Sci. 2007 Apr; 48(4):1900-5. PMID: 17389526

    Protective effect of TEMPOL derivatives against light-induced retinal damage in rats

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  • Free Radic Biol Med. 2006 Dec 15; 41(12):1847-59. PMID: 17157187

    Identification of 4-hydroxynonenal-modified retinal proteins induced by photooxidative stress prior to retinal degeneration

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  • Invest Ophthalmol Vis Sci. 2005 Oct; 46(10):3859-68. PMID: 16186375

    Protein modifications by 4-hydroxynonenal and 4-hydroxyhexenal in light-exposed rat retina

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  • Invest Ophthalmol Vis Sci. 2005 Apr; 46(4):1147-54. PMID: 15790872

    Detailed characterization of the lipid composition of detergent-resistant membranes from photoreceptor rod outer segment membranes

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  • Biochemistry. 2003 Jul 08; 42(26):7892-903. PMID: 12834341

    Cholesterol-dependent association of caveolin-1 with the transducin alpha subunit in bovine photoreceptor rod outer segments: disruption by cyclodextrin and guanosine 5'-O-(3-thiotriphosphate)

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  • J Biol Chem. 2002 Jan 11; 277(2):1469-76. PMID: 11705988

    Light-dependent association of Src with photoreceptor rod outer segment membrane proteins in vivo

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