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Jolyn Fernandes, MS, PhD

  • Membership Level: Diabetes Research Member

Biography

With a particular focus on metallomic and metabolomic strategies, the Fernandes lab uses diverse cellular and molecular integrated approaches to identify key molecular pathways that associate pre- and postnatal environmental exposures with offspring neurodevelopmental and metabolic disease susceptibility. Heavy metals are a risk factor for diabetes and metabolic dysregulation. As such a current focus in the Fernandes lab is to utilize high-resolution, high-throughput technologies to improve our understanding of the basis for differential disease susceptibility through early life nutritional and toxic metal exposures. Ultimately Dr. Fernandes lab aims to identify metabolic diagnostic biomarkers that could be developed for predictive therapeutic interventions in metabolic diseases.

Health Education
  • Graduate School
  • Postdoctoral Fellow, Division of Pulmonary, Allergy, Critical Care and Sleep Medicine Emory University School of Medicine
    Atlanta, GA
  • PhD, Biochemistry and Molecular Biology University of Oklahoma Health Sciences Center
    Oklahoma City, OK
  • Masters, Biochemistry The Institute of Science
    Mumbai, India,
  • University
  • Bachelors in Microbiology and Biochemistry St. Xavier's College
    Mumbai, India,
Notable Work
Mitochondria environmental stress signaling networks
Emory University, Atlanta, GA
Establish integrated omics networks to study adaptive and maladaptive hubs in mitochondria-cell signaling system that are impacted by environmental agents like manganese contributing to neurological disorders.

Role: Post-Doctoral Scholar

(Enzymology, metabolomics, transcriptomics, redox-proteomics, metals, cellular redox, oxidative stress, antioxidant responses, molecular signaling, neuronal mitochondrial bioenergetics, bioinformatics)

PI: Dr. Dean P. Jones, Dr. Young-Mi Go Kang

http://grantome.com/grant/NIH/R21-ES025632-02S1

Cytoplasmic-nuclear redox signaling: Disruption by dietary cadmium levels.

Emory University, Atlanta, GA

Targeted evaluation of dietary Cd health risks studies in mice through global proteomic and transcriptomic analysis along calibrated Cd-dependent markers of inflammation and fibrosis wherein Cd exposures at levels found in the American diet adversely impacts the mechanisms of cytoplasmicnuclear cell signaling of inflammation and fibrosis.

Role: Post-Doctoral Scholar

(Enzymology, metabolomics, transcriptomics, redox-proteomics, metals, cellular redox, oxidative stress, bioinformatics)

PI: Dr. Dean P. Jones, Dr. Young-Mi Go Kang

http://grantome.com/grant/NIH/R01-ES023485-01A1
 

Identify maternal prenatal metabolic pathways and metabolite correlations that link environmental exposures and preterm birth in African-American women.

Center for Children's Health, the Environment, the Microbiome and Metabolomics, Nell Hodgson School of Nursing, Emory University

Role: Post-Doctoral Scholar

(metabolomics, bioinformatics, metadata driven workflow)

PI: Dr. Dean P. Jones, Dr. Betsy Corwin, Dr.Shuzhao Li

http://www.nursing.emory.edu/c-chem2/index.html

Enhanced cardiac fatty acid utilization induced by high dietary fat: a potential regulatory role for mitochondrial aconitase.

Modulation of mitochondrial function by pro-oxidants

Role: Graduate Research Assistant

(enzymology, proteomics, post-translational modifications, cardiac mitochondrial bioenergetics)

Jolyn Fernandes, MS, Ph.D.

PI: Luke I. Szweda, Michael Kinter

https://grantome.com/grant/NIH/R01-AG016339-09