Tommy Lewis Jr., PhD

  • Research Program: Geroscience
  • Position: Adjunct - Biochemistry & Physiology, Assistant Member, OMRF

Biography

"Mitochondria are often referred to as the “powerhouse of the cell.” However, for something important enough to gain this reputation, we still have much to learn about the various roles mitochondria play in humans. My lab focuses on the function of mitochondria in neurons during both health and disease. We are interested in learning how neurons control our brain, and what goes wrong during aging leading to devastating neurodegenerative conditions like Alzheimer’s, dementia, and Parkinson’s.
Traditionally, we had to look at these cells outside the body in a dish but many times it is difficult to translate that work back into something relevant for treating human patients. We have developed a new imaging method where we can observe the function of mitochondria in living, relevant mouse models. As this research develops, we will be able to track what happens during disease progression in real-time. This may result in new avenues for understanding these traumatic diseases."

Email

Tommy-Lewis@omrf.org

Publications

Health Education
  • Graduate School
  • Postdoc in Neurobiology - Lab of Franck Polleux Scripps Research Institute/Columbia University
    San Diego/New York,
  • PhD in Molecular Biology University of Southern California - Lab of Don Arnold
    Los Angeles, CA
  • Undergraduate School
  • B.S. in Biology University of Southern California
    Los Angeles, CA
Research Interests:
  • Neural development
  • Mitochondria
  • Neurodegeneration
Publications
  • MFF-dependent mitochondrial fission regulates presynaptic release and axon branching by limiting axonal mitochondria size 2018
  • Progressive Decrease of Mitochondrial Motility during Maturation of Cortical Axons In Vitro and In Vivo 2016
  • AMP-activated protein kinase mediates mitochondrial fission in response to energy stress 2016
  • Terminal axon branching is regulated by the LKB1-NUAK1 kinase pathway via presynaptic mitochondrial capture 2013