Yusuke Takahashi, PhD
- Position: Diabetes Research Member
- Graduate School
- Doctoral Studies Tohoku University
- Master's Degree Tohoku University
- College
- Bachelor's Degree Ishinomaki Senshu University
- Regulatory role of microRNAs in diabetic retinopathy
- Discovery of new pathogenic mechanisms in diabetic complications, structure, and function of isomerohydrolase in the retinoid visual cycle
- Molecular basis of spectral tuning in visual pigments and adaptive evolution of color vision
Grant Funding
Ma, J.-X. (Principal Investigator), Takahashi, Y. (Co-Investigator),
"A new pathogenic mechanism for diabetic retinopathy.,"
R01, Sponsored by NIH, Federal
Grant/Contract Number: EY019309
Additional Information: The major goal of this project is to elucidate a novel pathogenic pathway in diabetic retinopathy and reveal a new therapeutic target
March 1, 2018 - February 28, 2022
Ma, J.-X. (Principal Investigator), Moyseiev, G. (co-PI), Takahashi, Y. (Co-Investigator),
"Studies of RPE65,"
R01, Sponsored by NIH, Federal
Grant/Contract Number: EY012231
Additional Information: The major goal is to study if impaired retinoid metabolism causes retinal diseases
February 1, 2019 - January 31, 2024
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Pathogenic Role of MicroRNA-21 in Diabetic Retinopathy Through Down-Regulation of PPARα. Diabetes
2017
Diabetes, 2017, 66, 1671-1682.,
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Influence of gestational diabetes mellitus on human umbilical vein endothelial cell microRNA
2016
Clinical Science, 2016, 130, 1955-1967
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Interaction of PPARalpha with the Wnt pathway, a mechanism for the therapeutic effect of fenofibrate on diabetic nephropathy
2016
Diabetes, 2016, 65, 3730-3743
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Receptor heterodimerization as a novel mechanism for regulation of Wnt/β-catenin signaling
2014
J. Cell Sci., 2014, 127, 4857-4869.
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Identification of key residues determining isomerohydrolase activity of human RPE65
2014
J. Biol. Chem., 2014, 289, 26743-26751. PMCID: PMC4175317.
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Therapeutic Potential of a Monoclonal Antibody Blocking the Wnt Pathway in Diabetic Retinopathy
2012
Diabetes, 2012, 61, 2948-2957.
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Identification of the key residues determining the product specificity of isomerohydrolase
2012
Biochemistry, 2012, 51, 4217-4225. PMCID: PMC3358571.
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Implication of dysregulation of the canonical wingless-type MMTV integration site (WNT) pathway in diabetic nephropathy
2012
Diabetologia, 2012, 55, 255-266.
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Identification of a Novel Palmitylation Site Essential for Membrane Association and Isomerohydrolase Activity of RPE65
2009
J. Biol. Chem., 2009, 284, 3211-3218. PMCID: PMC2631947.
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Two-point mutations of RPE65 from patients with retinal dystrophies decrease the stability of RPE65 protein and abolish its isomerohydrolase activity
2006
J. Biol. Chem., 2006, 281, 21820-21826.
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RPE65 is the isomerohydrolase in the visual cycle
2005
Proc. Nat. Acad. Sci. U.S.A., 2005, 102, 12413-12418. PMCID: PMC1194921.
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Tertiary structure and spectral tuning of UV and violet pigments invertebrates.
2005
Gene, 2005, 365, 95-103.
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Molecular basis of spectral tuning in the newt short-wavelength sensitive visual pigment.
2003
Biochemistry, 2003, 42, 6025-34.
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Distribution of blue-sensitive photoreceptors in amphibian retinas
2001
FEBS Lett. 2001, 501, 151-155.
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Primary structure of visual pigment in bullfrog green rods
1999
FEBS Lett., 1999, 447, 44-48.
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Genetic basis of spectral tuning in the violet-sensitive visual pigment of African clawed frog, Xenopus laevis
Genetics, 2005, 171, 1153-1160. PMCID: PMC1456818.
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MiRNA-451a regulates RPE function through promoting mitochondrial function in proliferative diabetic retinopathy
Am. J. Physiol. Endocrinol. Metab., 2019, 316, E443-E452, DOI: 10.1152/ajpendo.00360.2018.
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MicroRNA-200b downregulates oxidation resistance 1 (Oxr1) expression in the retina of type 1 diabetes model
Invest. Ophthalmol. Vis. Sci., 2013, 54, 1689-1697., (*Corresponding author). PMCID: PMC3626515.
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MicroRNA-184 modulates canonical Wnt signaling through the regulation of frizzled-7 expression in the retina with ischemia-induced neovascularization
FEBS Lett., 2015, 589, 1143-1149, (*Corresponding author). PMCID: PMC4406844.